摘要 :
Nanomedicine-enabled/augmented ultrasound (US) medicine is a unique area of interdisciplinary research that focuses on designing and engineering functional nanosystems to address the challenging issues in US-based biomedicine, ove...
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Nanomedicine-enabled/augmented ultrasound (US) medicine is a unique area of interdisciplinary research that focuses on designing and engineering functional nanosystems to address the challenging issues in US-based biomedicine, overcoming the shortcomings of traditional microbubbles and optimizing the design of contrast and sonosensitive agents. The single-faceted summary of available US-related therapies is still a significant drawback. Here, The proposal of a comprehensive review on the recent advances of sonosensitive nanomaterials in advancing four US-related biological applications and disease theranostics is aimed. In addition to the mostly explored nanomedicine-enabled/augmented sonodynamic therapy (SDT), the summary and discussion of other sono-therapies and progresses/achievements are relatively lacking, including sonomechanical therapy (SMT), sonopiezoelectric therapy (SPT), and sonothermal therapy (STT). The design concepts of the specific sono-therapies based on nanomedicines are initially introduced. Furthermore, the representative paradigms for nanomedicine-enabled/enhanced US therapies are elaborated according to therapeutic principles and diversity. This review provides an updated and comprehensive review of the field of nanoultrasonic biomedicine, and comprehensively discusses the progress of versatile ultrasonic disease treatments. Finally, the deep discussion on the facing challenges and prospects is expected to promote the emergence and establishment of a new branch of US biomedicine through the rational combination of nanomedicine and US clinical biomedicine.
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摘要 :
Photothermal therapy (PTT) and sonodynamic therapy (SDT) using nanomaterials are in progress as alternative modality of cancer therapy. Herein, a nanocomposite comprising MnFe2O4 and carbon (MnFe2O4/C) was synthesized and characte...
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Photothermal therapy (PTT) and sonodynamic therapy (SDT) using nanomaterials are in progress as alternative modality of cancer therapy. Herein, a nanocomposite comprising MnFe2O4 and carbon (MnFe2O4/C) was synthesized and characterized by field emission scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, vibrating sample magnetometery and X-ray diffraction. MnFe2O4/C had a saturation magnetization of 13.250 emu g(-1), a coercivity of 13.204 G and a magnetic moment of 0.55, and comprised uniform spherical particles with a mean diameter of 221.6 +/- 22 nm and cracked surface. The spheres had a carbon entity accompanied by embedded cubic spinet-type MnFe2O4 dots of 2.1 0.6 nm in diameter. MnFe2O4/C was then introduced as a new absorbing agent of both 808-nm laser light and ultrasound (US) wave in treatment of C540 (B16/F10) cancer cells and melanoma tumor bearing mice. Simultaneously, MnFe2O4/C can act as a contrast agent for magnetic resonance imaging. While MnFe2O4 C was relatively biocompatible both in vivo and in vitro, and 808-nm laser light and US waves of 1.0-MHz had negligible effects on the tumor cells, the laser light and US waves at power densities of 0.5 and 1.0 W cm(-2) activated MnFe2O4/C to kill the C540 (B16/F10) cancer cells and destroyed the tumor. Cell viability upon irradiation of both the laser light and US in the presence of 25 mu g mL(-1) MnFe2O4/C reached 21.5 and 4.6% at the power densities of 0.5 and 1.0 W cm(-2), respectively. On the other hand, histological analyses indicated that intratumoral injection of MnFe2O4/C along with laser light and US irradiations led to a deep tumor tissue necrosis. A highly contrast induction in the magnetic resonance images of MnFe2O4/C along with its PTT and SDT efficacies introduced it as a novel theranostic agent in nanomedicine. (C) 2019 Elsevier B.V. All rights reserved.
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Chemodynamic therapy (CDT) employs Fenton catalysts to kill bacteria by converting hydrogen peroxide (H2O2) into toxic hydroxyl radical ( center dot OH). Among them, Fenton-type metal peroxide nanoparticles fasci-nate nanomaterial...
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Chemodynamic therapy (CDT) employs Fenton catalysts to kill bacteria by converting hydrogen peroxide (H2O2) into toxic hydroxyl radical ( center dot OH). Among them, Fenton-type metal peroxide nanoparticles fasci-nate nanomaterials with intriguing physiochemical properties, but research on this antibacterial agent is still in its infancy. Herein, a distinct CuO2/TiO2 heterostructure constituted of ultrasmall copper per-oxide (CuO2) nanoclusters and sonosensitized ultrathin oxygen vacancy-rich porous titanium oxide (OV-TiO2) nanosheets was developed and was incorporated into microneedles for bilaterally augmented sono-chemodynamic and sonothermal antibacterial therapy. Engineering CuO2 nanoclusters on the surface of TiO2 nanosheets not only endows the Fenton catalytic activity for sono-chemodynamic therapy (SCDT), but also improves the sonodynamic and sonothermal performance of TiO2 by narrowing the bandgap of TiO2 and suppressing the recombination of electron-hole pairs. The high efficacy of this CuO2/TiO2 in-tegrated microneedle (CTMN) patch was systematically demonstrated both in vitro and in vivo with the eliminating rate > 99.9999% against multidrug resistant (MDR) pathogens in 5 min as well as accelerated wound tissue healing. This work highlights a promisingly new and efficient strategy for the development of sonosensitive and chemoreactive nanomedicine for non-antibiotic therapies.Statement of significance Feton-type metal peroxides, a novel nanomaterial with self-supplied oxygen and hydrogen peroxide, can achieve effective antimicrobial activity in vitro. However, there is a lack of effective nanomaterial delivery systems and suitable means for in vivo activation/enhancement of antimicrobial activity during bacterial infected skin wound treatment. In this study, we designed and prepared efficient ultrasound activable mi-croneedles that effectively addressed the deficiencies mentioned above and established a new paradigm for efficient utilization of metal peroxide nanomaterials and ultrasound based strategies. Noticeably, cop-per peroxide nanoclusters/oxygen vacancy-rich porous titanium oxide nanosheets (CuO2 /TiO2) integrated microneedle (CTMN) patch combines advantages of both sono-chemodynamic and sonothermal antibac-terial therapy, achieving one of the most instant and effective antibacterial efficacy ( > 99.9999% in 5 min) in vivo reported till now.(c) 2022 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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